Magnetic Particle Imaging
Magnetic Particle Imaging (MPI) is a novel tomographic method for determining the distribution of magnetic material in three dimensions. Similar to Magnetic Particle Spectroscopy (MPS), MPI is based on the nonlinear magnetization response of magnetic iron oxide nanoparticles (MNP) to dynamic magnetic fields. Additional strong magnetic field gradients are used to encode the field of view (FOV) by selectively generating higher harmonics near the encoding scheme. The encoding scheme can have different shapes, such as field-free point (FFP) or field-free line (FFL), which can be moved through the FOV in a variety of ways (trajectories) [1,2,3].
Similar to PET or SPECT, MPI is a tracer-based method, which comes with a lot advantages, such as high spatial resolution , high sensitivity  and high temporal resolution . These features build a promising new technology for different fields, such as material science, biology, chemistry, and medicine. Especially the latter field shows some interesting developments in the last decade, e.g., MPI as a promising tool for future intervention, such as PTA or stenting [7-12], but also novel scanner designs for human-sized applications [13-17].
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 J. Sedlacik et al., Magnetic particle imaging for high temporal resolution assessment of aneurysm hemodynamics, PLoS ONE, vol. 11(8):e0160097, 2016.
 J. Salamon, et al. Magnetic particle / magnetic resonance imaging: in-vitro MPI-guided real time catheter tracking and 4D angioplasty using a road map and blood pool tracer approach, PLoS ONE, vol. 11(6):e0156899, 2016.
 J. Haegele et al., Toward cardiovascular interventions guided by magnetic particle imaging: first instrument characterization, Magn Reson Med, vol.69(6), pp. 1761-7, 2013.
 M. Graeser et al., Human-sized magnetic particle imaging for brain applications, Nature Comm, vol. 10:1936, 2019.
 E. E. Mason, et al. Design analysis of an MPI human functional brain scanner, Int. J. Magn. Part. Imaging, vol. 3(1):1703008, 2017.
 P. Vogel et al. iMPI – portable human-sized Magnetic Particle Imaging Scanner for real-time endovascular Interventions, PREPRINT (Version 1) available at Research Square, doi:10.21203/rs.3.rs-2294644/v1, 2022
 P. Vogel et al. Realtime iMPI-guided PTA with a lightweight human-sized MPI scanner, Int. J. Magn. Part. Imaging, vol. 9(1):2303024, 2023.
 J. Günther et al. Human-sized Lightweight Head-Scanner Design, Int. J. Magn. Part. Imaging, vol. 8(1):2203064, 2022.
 P. Vogel, et al. Traveling Wave Magnetic Particle Imaging, IEEE Trans Med Imaging., vol. 33(2), pp. 400–407, 2014.
 P. Vogel et al., Dynamic Linear Gradient Array for Traveling Wave Magnetic Particle Imaging, IEEE Trans Magn, vol. 54(2): 5300109, 2018.
 P. Vogel et al. Parallel Magnetic Particle Imaging, Rev. Sci. Instrum., vol. 91(4):045117, 2020.
 P. Vogel et al. Suerspeed Traveling Wave Magnetic Particle Imaging, IEEE Trans Magn, vol. 51(2):6501603, 2015.
 P. Vogel, et al., Adjustable hardware lens for Traveling Wave MPI, IEEE Trans Magn, vol. 56(11):5300506, 2020.
 P. Vogel, et al., Magnetic Particle Imaging meets Computed Tomography: first simultaneous imaging, Sci Rep, vol. 9:12672, 2019.
 P. Vogel et al. MRI meets MPI: a bimodal MPI-MRI tomograph, IEEE TMI, vol. 33(10), pp. 1954-9, 2014.
 P. Klauer et al. Bimodal TWMPI-MRI Hybrid Scanner – Coil Setup and Electronics, IEEE Trans Magn, vol.51(2):5300504, 2015.
 C. Greiner et al. Traveling Wave MPI utilizing a Field-Free Line, Int. J. Magn. Part. Imaging, vol. 8(1):2203027, 2022.
 P. Vogel et al., Highly Flexible and Modular Simulation Framework for Magnetic Particle Imaging, arXiv:2208.13835, 2022.
 P. Vogel, T. Kampf, M.A. Rückert, V.C. Behr, Flexible and Dynamic Patch Reconstruction for Traveling Wave Magnetic Particle Imaging, International Journal on MPI, vol. 2(2):1611001, 2016.
 P. Vogel, et al., Low Latency Real-time Reconstruction for MPI Systems, Int. J. on MPI, vol. 3(2):1707002, 2017.
 S. Herz et al. MPI-guided endovascular therapy of 3D printed human aneurysm, Int. J. on MPI, vol.9(1):2303065, 2023.
- innovative 3D imaging
- dynamic field-free line encoding
- traveling wave MPI
- 5 channel transmit system
- bore size: 15 mm
- gradient strength: up to 1 T/m
- AQ time per 3D image: 20 ms
- open Matlab interface
Highly flexible and modular setup:
- vertical or horizontal scanner design
- arbitrary sequences & trajectories
- modular amplifier cabinet
- gradient strength: up to 15 T/m
- frequencies: DC…10 kHz
- scalable bore size: up to 25 cm